Dr. Seth Sengretsi was born on the 17th of March, 1953 to Togbe Fosuhene III, chief of Wusuta, Anyinabase and Madam Abena Badu of Hoeme, Wusuta, both of blessed memory. He spent his early years at Papase with his mother which earned him the nickname Papase on his return.

He started his education at E.P. School in Wusuta, both primary and middle schools. He finished in 1967 and gained a scholarship to St. Paul’s Secondary School in Denu, from 1967 – 1972. He continued his sixth form at St. Augustine’s College between 1972 – 1974 and from there to the University of Ghana Medical School. He graduated in 1980.